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KMID : 0384119910110030549
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Korean Journal of Clinical Pathology
1991 Volume.11 No. 3 p.549 ~ p.556
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A Study of DNA Ploidity in non-Hodgkin's Lymphoma
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J. H. Park
J. W. Kim/C. B. Im/S. H. Koo/J. W. Park
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Abstract
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It has been known that the DNA ploidity and the fraction of systhetic phase in cell cycle analysis were closely related with pathological grade and clinical stage of malignancy. So we have done flow cytometric analysis at 24 patients, pathologically diagnosed to non-Hodgkin`s lymphoma, to prove the correlations between the each parameters. The results are as follows. 1. There was aneuploidity in 80% of pathologically high grade non-Hodgkin`s lymphoma patients and in 16.7% of pathologically intermediate grade non-Hodgkin`s lymphoma. The differences of frequency of aneuploidity between two groups were statistically significant (p=0.017) 2. Although clinically higher stage lymphomas tend to have higher frequency of aneuploidity, there was no statistically significant correlation between frequency of aneuploidity and clinical stage of lymphoma. 3. Flow cytometric proliferative activity in the point of GO/G1% ration or fraction of synthetic phase cells is not correlated with pathological trade of lymphoma. 4. Between clinical stage of lymphoma and flow cytometric proliferative activity, there was no statistically significant correlation. Because of small population in this study, statistically significant correlation between flow cytometric parameters such as DNA aneuploidity or fraction of synthetic phase cells and clinical stage and pathological grade of lymphoma was not obtained. But, the parameters of flow cytometric analysis such as DNA aneuploidity and ration of synthetic phase cells may be correlated with pathological grade and clinical stage of malignant diseases including lymphoma, if prospective large scale study is performed.
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